Download BookmTOR Pathway and mTOR Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development)

Download PDF mTOR Pathway and mTOR Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development)

Download PDF mTOR Pathway and mTOR Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development)

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The main objective of this book is to provide an up-to-date survey of the rapidly advancing eld of cancer therapy. Moreover, since our knowledge in this area rapidly evolves, some data have got obsolete during the process of book editing. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer treatment – targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines. The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. In mammalian cells, mTOR exists in at least two multi-protein complexes that have critical roles in regulating cellular homeostasis and survival. As with many other areas of science, discovery of TOR signaling was fortuitous. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island). Rapamycin was rst discovered to be a potent antifungal agent and next as an immune suppressive drug. It was only later that it was found to be active as an antitumor agent in non-clinical models; although it was not developed for this indication. The history of rapamycin presents one of the rst examples of chemical genetics. Wnt signaling pathway - Wikipedia History. The discovery of Wnt signaling was influenced by research on oncogenic (cancer-causing) retroviruses. In 1982 Roel Nusse and Harold Varmus infected mice with mouse mammary tumor virus in ... Cancer growth blockers Cancer Research UK Cancer growth blockers (cancer growth inhibitors) are a type of biological therapy. They can make cells grow or divide or stop cells growing and make them die. ... A cancer growth blocker blocks ... Drug Resistance and Molecular Cancer Therapy: Apoptosis Versus ... Drug Resistance and Molecular Cancer Therapy: Apoptosis Versus Autophagy InTechOpen Published on: 2013-05-15. Authors: Rebecca T. Marquez Bryan W. Tsao Nicholas F. Faust et ... Figure 1 ... PI3K and cancer: lessons challenges and opportunities : Nature ... Next article. Nature Reviews Drug Discovery Correspondence A new roadmap for drug development for Alzheimer's disease PI3K and cancer: lessons challenges and opportunities. David A ... Mechanistic target of rapamycin - Wikipedia Discovery. mTOR was first named as the mammalian target of rapamycin. Rapamycin (sirolimus) was discovered in a soil sample from Easter Island known locally as Rapa Nui in the 1970s. The ... Everolimus in Postmenopausal Hormone-ReceptorPositive Advanced ... BackgroundResistance to endocrine therapy in breast cancer is associated with activation of the mammalian target of rapamycin (mTOR) intracellular signaling pathway. In early studies the mTOR ... ... Metabolic targets for cancer therapy : Nature Reviews Drug Discovery ... Abstract Key points Introduction Systemic metabolism and cancer Cancer and cellular metabolism Targeting cancer metabolism Concluding remarks Change history References Cancer Abcam Cancer research protocols articles tools and events. Find information on cell growth invasion and cancer metabolism. ... Autonomous uncontrolled cell growth and proliferation are the ... Media PIQUR Therapeutics AG Disclaimer No warranty and no liability The material provided in this site is presented solely to improve public access to information about PIQUR Therapeutics AG. PIQUR Therapeutics AG will make ... Evaluating the evolving evidence: The challenges of molecular ... Figure 1. Molecular targets and inhibitory agents in advanced gastric cancer. AKT = protein kinase B; cSRC = tyrosine protein; EGFR ...
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